Taking Effexor XR with aspirin, nonsteroidal anti-inflammatory drugs, warfarin, or other blood thinners may increase the risk of bleeding events. Some people are at risk for visual problems such as eye pain, changes in vision, or swelling or redness around the eye. G'day.I've been on Effexor XR 150mg a day for some 10 years,I have severe agoraphobia and panic disorder.Originally the dose worked well for me but slowly over the years the benefits have diminished and I'm slipping backwards. Find information about common, infrequent and rare side effects of Effexor XR Oral. Find patient medical information for Effexor XR Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Depressed patients who are currently being treated at a therapeutic dose with Effexor (immediate release) may be switched to Effexor XR at the nearest equivalent dose (mg per day), e.g., 37.5 mg venlafaxine twice a day to 75 mg Effexor XR once daily. However, individual dosage adjustments may be necessary. I just started taking Effexor XR (37.5mg) 5 days ago and am schedule to increase to 75mg in 2 more days. I suffered a lot of side effects the first 3 days and am my question is will I get those same side effects when I increase the dose? I used to take 300Mgs a day of Effexor XR for 4 years (before it pooped out on me) Anyway there is something that you need to know about Effexor XR (Venlafaxine) that is that at or below the 150Mg dosage mark Effexor is simply just another SSRI and has no SNRI action. Hey there, I have been taking Effexor XR for 4 weeks (37.5mg week 1 and 75mg for 3 weeks). I was taken off Zoloft after 10 years. I had a 4 week appointment on Thursday and my doctor increased my dosage to 150mg (Once in the morning) because we both felt that 75mg was working but was not the theraputic dosage. Medscape - Depression-specific dosing for Effexor, Effexor XR (venlafaxine), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information. Detailed dosage guidelines and administration information for Effexor XR (venlafaxine hydrochloride). Includes dose adjustments, warnings and precautions.